I was on Humira for 4 months and was almost pain free in about 48 hours. I was definitely very immune compromised on it and had a number of infections right out of the gate - strep, anti-biotic resistant UTI and then leveled out. Unfortunately, I developed antibodies to it and it completely stopped working within 4 months. I was switched to enbrel, which was not nearly as effective for me and then added methotrexate in. Still not nearly as effective as humira was before the antibodies.
