JC,

Also that TNF can be expressed readily by fat cells....less fat less TNF expressed?

http://www.diabetesincontrol.com/issue199/rosen.shtml

http://www.jci.org/cgi/content/full/112/12/1821

Taking pressure of the Bowel, many colitis/chron's sufferer report improvements after the prep cleanse etc....

Fasting....maybe it puts you in a fight/flight state....more endomorphs blood changes etc....

there's so many possible answers, but reducing weight if you can can only help! Even carrying an extra couple of kils I'm more sore and stiff

David