The rheumy said we could switch me to every 10 days instead of every 14 days like he does for his crohn's patients, but then the risk of Humira wearing off for good (antibodies against) increases or so it seems, so I told him we'd try to stick to the 14 day schedule.
Hi Sue,.. this is off topic but I thought you might be interested, since I think current research seems to be leaning toward the opposite conclusion in regard to dose.
Immunogenicity
Patients in Studies RA-I, RA-II, and RA-III were tested at multiple time points for antibodies to adalimumab during the 6-to 12-month period. Approximately 5% (58 of 1062) of adult RA patients receiving HUMIRA developed low-titer antibodies to adalimumab at least once during treatment, which were neutralizing in vitro. Patients treated with concomitant methotrexate (MTX) had a lower rate of antibody development than patients on HUMIRA monotherapy (1% versus 12%). No apparent correlation of antibody development to adverse reactions was observed. With monotherapy, patients receiving every other week dosing may develop antibodies more frequently than those receiving weekly dosing. In patients receiving the recommended dosage of 40 mg every other week as monotherapy, the ACR 20 response was lower among antibody-positive patients than among antibody-negative patients. The long-term immunogenicity of HUMIRA is unknown.You might find this interesting, from Medscape:
Antidrug Antibodies (ADAb) to Tumour Nec...matory Diseases Will be great to have more research to give us all a better guide on these sorts of decisions.
Cheers!
mig
