Hello, I have been on the Enbrel injections since this past January. The injection site reaction is the most pronounced side effect that I've experienced thus far. For me it's not just itchy and red, there's also a painful knot that accompanies the irritation. I can't really tell if they're helping or not. My pain levels and range of motion aren't any different than when I began the meds. I don't think I should give up on it yet though. Hopefully you are having a better experience with it.