Sherri, forgive me for not knowing your previous symptoms of your knees, other than what you just mentioned "pain". I have been gone a long time, but as the "old-timers" know, my main affliction was "melon knee". I think I described the pain as "cutting open my knee and pouring battery acid in it". (btw--I would always have a "flare" in one or the other never both at the same time) To this day, i really have nothing "wrong" medically with my knees, i.e. no torn acl, no miniscus tear etc. Since enbrel, I can run, jump, dance, volley, etc. The pain was caused by my overproduction of cells in the lining of my knees aka synovial fluid and an occasional bout with gout. In the days before Enbrel, I would have my knees aspirated to the tune of 800ml per knee and cortisone injections etc. . Sometimes the relief would last 2 months, sometimes 2 days. Once I got A.S. under control, the swelling and pain does not re-occur. I hope this helps. Warmest, Teresa