Hi Sue,
I had to stop taking it because I couldn't sleep and gained ten Ibs. I was off of it for four months and had still good relief for three of those months. It can last in your system for up to four months. I just started back on it four weeks ago, and noticed a little improovemt. You won't get any site reactions until it starts decreasing your immune system and the your injection sites will get red,like a hive and itchy. That is when you will notice it is really working. That happened on the fourth week for me.Some folks take months to noice a difference.

Janet
P.S
It really is very exciting when yo really start to improove. Try to get all the things done that you have put off. I cleaned my ouse from top to bottom. We also took a nice cruise.